Based on the good writing about the goal of Fedora.next by Adam Williamson, Design Suite may be made on top of Fedora Workstation as the logical choice. Doing so will help focusing on key areas like configurations and proper distribution of applications to display better technologies (For example, Design Suite is using AppFolder provided by Gnome Shell as default). Fedora Workstation is a base with the ability to add group package like Design Packages in this case. Only difference with the spin is the optimization while staying close to upstream.
While waiting for a bug fix affecting majority of 2-in-1 laptops running on GNOME Wayland session, gnome-shell-extension-screen-autorotate is now available in Fedora repository and EPEL 9 . Give a try on your device Possibly this extension will get added on the incoming Fedora Design Suite 39 as default for the owners of convertible laptops.